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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: WEE1 All Species: 15.15
Human Site: S203 Identified Species: 25.64
UniProt: P30291 Number Species: 13
    Phosphosite Substitution
    Charge Score: -0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P30291 NP_003381.1 646 71597 S203 S K A R G I D S S S V K L R G
Chimpanzee Pan troglodytes XP_521839 646 71607 S203 S K A R G I D S S S V K L R G
Rhesus Macaque Macaca mulatta NP_001099016 568 63102 F158 A L V N I N P F T P E S Y R K
Dog Lupus familis XP_534051 887 95991 S444 S K A R G I D S S S V K L R G
Cat Felis silvestris
Mouse Mus musculus P47810 646 71560 D202 L S K A R V I D S G S V K L R
Rat Rattus norvegicus Q63802 646 71478 S203 S K A R V I D S S S V K L R G
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001510171 572 63943 P162 T P Q V N I N P F T P D S M L
Chicken Gallus gallus NP_001026352 641 70947 S199 A Q G L G S S S V K L R G G S
Frog Xenopus laevis P47817 555 61670 V144 E L D D P S L V N I N P F T P
Zebra Danio Brachydanio rerio NP_001005770 612 68517 K190 S K A C L D G K R N Q T P R V
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P54350 609 68790 N191 E N L N L N V N A M Q K Y L L
Honey Bee Apis mellifera XP_624069 589 66032 A179 P N G M L L T A R K R T R S K
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus NP_999796 624 68925 N198 A R P H T A P N M R N L Q R R
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q8L4H0 500 56512 K90 S D A N C G E K D F I L S Q D
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.5 42.1 70.9 N.A. 90.5 91.6 N.A. 72.7 80.1 42.8 64.2 N.A. 36.5 41.6 N.A. 39.6
Protein Similarity: 100 99.8 56.1 71.3 N.A. 92.7 93.1 N.A. 79.2 85.9 55.2 75 N.A. 54.1 59.2 N.A. 55.5
P-Site Identity: 100 100 6.6 100 N.A. 6.6 93.3 N.A. 6.6 13.3 0 26.6 N.A. 6.6 0 N.A. 6.6
P-Site Similarity: 100 100 20 100 N.A. 13.3 93.3 N.A. 26.6 40 6.6 33.3 N.A. 20 13.3 N.A. 26.6
Percent
Protein Identity: N.A. N.A. N.A. 23 N.A. N.A.
Protein Similarity: N.A. N.A. N.A. 38.8 N.A. N.A.
P-Site Identity: N.A. N.A. N.A. 13.3 N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. 33.3 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 22 0 43 8 0 8 0 8 8 0 0 0 0 0 0 % A
% Cys: 0 0 0 8 8 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 8 8 8 0 8 29 8 8 0 0 8 0 0 8 % D
% Glu: 15 0 0 0 0 0 8 0 0 0 8 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 8 8 8 0 0 8 0 0 % F
% Gly: 0 0 15 0 29 8 8 0 0 8 0 0 8 8 29 % G
% His: 0 0 0 8 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 8 36 8 0 0 8 8 0 0 0 0 % I
% Lys: 0 36 8 0 0 0 0 15 0 15 0 36 8 0 15 % K
% Leu: 8 15 8 8 22 8 8 0 0 0 8 15 29 15 15 % L
% Met: 0 0 0 8 0 0 0 0 8 8 0 0 0 8 0 % M
% Asn: 0 15 0 22 8 15 8 15 8 8 15 0 0 0 0 % N
% Pro: 8 8 8 0 8 0 15 8 0 8 8 8 8 0 8 % P
% Gln: 0 8 8 0 0 0 0 0 0 0 15 0 8 8 0 % Q
% Arg: 0 8 0 29 8 0 0 0 15 8 8 8 8 50 15 % R
% Ser: 43 8 0 0 0 15 8 36 36 29 8 8 15 8 8 % S
% Thr: 8 0 0 0 8 0 8 0 8 8 0 15 0 8 0 % T
% Val: 0 0 8 8 8 8 8 8 8 0 29 8 0 0 8 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 15 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _